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پاورپوینت در مورد The Role of Polymorphisms near

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پاورپوینت در مورد The Role of Polymorphisms near

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نوع فایل :  powerpoint (..ppt) ( قابل ويرايش و آماده پرينت )

تعداد اسلاید : 29 اسلاید

 قسمتی از متن powerpoint (..ppt) : 

The Role of Polymorphisms near IL28B Gene on Response to Peg-Interferon and Ribavirin in Thalassemic Patients with Hepatitis C

The transfusion-dependent thalassemic patients are at higher risk of acquiring HCV infection especially those who received their first transfusion in Iran before 1995 .

Hepatitis C virus seroprevalence in Iranian thalassemic patients is approximately 18% .

Liver failure as the consequence of HCV infection is the second cause of mortality in thalassemic patients .

Also, Iron overload following frequent blood transfusion deteriorates liver fibrosis in these patients.

A study on 280 thalassemic patients with hepatitis C who were treated with PEG-IFN monotherapy or PEG-IFN and RBV showed that the addition of RBV to PEG-IFN increased the rate of SVR especially in patients with HCV genotype-1.

TABATABAEI S V; et al. Hepat Mon 2012

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